gene mutation ppt

duplications can all be frameshift mutations. Barn swallow. AQA Biology Unit 5 Gene Mutation. tonr mutation occurring early in proliferation ? Chromosomes/DNA Mutations Chromosome Mutation Mutations are permanent gene or chromosome changes that will be passed on to offspring if they occur in a gamete Two ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 7cc5d8-ZmQ1Z have no effect on the amino acid produced by a codon because of redundancy in the genetic code. Types of Gene Mutations :Types of Gene Mutations Include: Point Mutations … • TYPES OF GENE MUTATION Mutations that occur in germ cells (sperm, eggs) are passed on to offspring. Mutations in many bacteria that allow them to survive in the presence of antibiotic drugs. Such mutations lead to evolution. 3. Types. The frequency of mutation for a gene is calculated as follows: Frequency of gene mutation = M / M + N . The mutation protects them from developing atherosclerosis, which is the dangerous buildup of fatty materials in blood vessels. The mutation may result due to changes either on the gene or the chromosome itself. The mutation is a process that produces a gene or chromosome that differs from the wild type (arbitrary standard for what “normal” is for an organism). Genetic & Non-genetic afftg Dairy cows. Mobile elements and mutations ... Lecture 7 DNA repair Chapter 10 Problems 2, 4, 6, 8, 10, 12, and 14, - Lecture 7 DNA repair Chapter 10 Problems 2, 4, 6, 8, 10, 12, and 14 Quiz 3 due today at 4:00 PM. To view this presentation, you'll need to allow Flash. ie. • TYPES OF MUTATION ... Vole. 4.7 9 customer reviews. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Chromosomal mutations are the change in chromosome structure. Mutation may be the change in gene, chromosome or plasmagene (genetic material inside mitochondria and chloroplasts. • RECENT RESEARCH Mutations That Occur In Germ Cells (sperm, Eggs) Are Passed On PPT. mutation rate. 15. - DNA Mutation And Repair Base Mismatch Repair DNA polymerase proofreads itself, but makes an error every approx. Spontaneous mutation- Spontaneous mutation occurs naturally without any cause. Scope for value addition in Milk. This resource is designed for UK teachers. Now customize the name of a clipboard to store your clips. Gene mutations. Mutations Missense A type of point mutation that results in a change in a single mutation. An insertion changes the number of DNA bases in a gene by adding a piece of DNA. Overview. Mutations by Chemicals: ADVERTISEMENTS: Alkylating Agents: This is the most powerful group of mutagens. Gene Therapy Ppt - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. They are all artistically enhanced with visually stunning color, shadow and lighting effects. Also called a base-pair substitution, this type of mutation changes a single nucleotide base pair. The PPT1 gene mutations that cause CLN1 disease decrease or eliminate the production or function of palmitoyl-protein thioesterase 1. Gene Mutation is a permanent change in the DNA sequence that makes up a gene. Also called a base-pair substitution, this type of mutation changes a single nucleotide base pair. Gene Mutation. GENE MUTATIONRefers to thechange in the sequenceof nucleotide bases ofthe DNA that corresponds to a particular gene. Mutations in somatic (body) cells may be harmless, or may result in disease such as Point Mutations - Point Mutations A mutation is a change in an organism s DNA. tonr mutation occurring late in proliferation ? Gene Mutation. mutations are silent because the encoded amino acid remains the same or the amino acid substitution is sufficiently subtle so as not to compromise activity of the enzyme. It's FREE! ADVERTISEMENTS: 2. 1. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. Mutations range in size from a single DNA building block (DNA base) to a large segment of a chromosome. Chromosomal Mutations. - Title: Unit 3 Information pathways of gene Author: biochem Last modified by: biochem Created Date: 3/2/2005 3:22:26 AM Document presentation format, Heredity, Gene Regulation, and Development, - Heredity, Gene Regulation, and Development Mutation A. Overview. Many kinds of gene mutations can occur, especially during DNA replication. Biology 3.3 - Describe the role of DNA in relation to gene expression, - Biology 3.3 - Describe the role of DNA in relation to gene expression Dr Hayley Ridgway Ms Dalin Dore, | PowerPoint PPT presentation | free to view. 6. C. G. C. G. C. A. and. mutation powerpoint. • EFFECT OF GENE MUTATION Carousel Previous Carousel Next. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Also known as base pair substitution. sdrm group 4.pptx. Instead of sub - stituting one amino acid for another, however, the altered DNA sequence Rate of spontaneous mutation is higher in eukaryotes than prokaryotes. Molecular Mechanism of Mutations - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. • MOLECULAR MECHANISM OF GENE MUTATION This website and its content is subject to our Terms and Conditions. In vivo the 0-6 position of guanine and the 0-4 of thymine are preferred. Types of Mutations Point Mutations Transfer Mutations In these mutations, extra chromosomes (or parts of chromosomes) transfer into the sperm or egg. You can change your ad preferences anytime. Overview. Presented by: Anirudh Acharya, Department of Zoology, University of Mysore. THE GENE 5’ Promoter Ex1 in1 Ex2 In2 Ex3 In-- Ex----3’ POLYMORPHISM Polymorphism is change with no effect in the phenotype. Change in a single nucleotide base pair. The molecular basis of structural damage ... Chapter 1 Gene targeting, principles,and practice in mammalian cells. Mutations can occur either in non-coding or coding sequences Mutation in the coding sequence is recognized as an inherited disorder or disease MUTATION. The mutation produced by change in the base sequence of gene is called point mutation or gene mutation. 3 What is a gene mutation? The mutation produced by change in the base sequence of gene is called point mutation or gene mutation. • GENE MUTATION Mutations happen regularly Almost all mutations are neutral Chemicals & UV radiation cause mutations Many mutations are repaired by enzymes Are Mutations Helpful or Harmful? (c) Most genes belong to larger gene families of shared ancestry, detectable by their sequence homology. Mutations: Changes In Genes Point Mutations A Point Mutation Is A PPT Presentation Summary : Mutations: Changes in Genes Point Mutations A point mutation is a change in a single base pair in the DNA. Many kinds of mutations can occur, especially during replication. change an amino acid codon into a stop codon, … Explain the difference between a simple reversion and a suppressor mutation ... - DNA replication and repair - Lecture 3 Jim Borowiec September 28, 2006 Pathway of Carcinogenesis Non-repaired mismatch DNA replication Non-critical gene or non-coding ... - Each of the parental strands serves as a. template for a ... round of replication, or if improperly repaired. Thus, broadly mutation maybe: Gene mutation where the allele of a gene changes. They transfer alkyl groups to the nitrogen atoms of the bases in DNA. Because most mutations are deleterious, there are limits to the number of ... DNA Mutation And Repair Base Mismatch Repair DNA polymerase. View Notes - 7.2 Gene Mutation full note.ppt.pptx from GLT 1009 at University of Malaya. It is a heritable change […] Mutations happen regularly Almost all mutations are neutral Chemicals & UV radiation cause mutations Many mutations are repaired by enzymes. Looks like you’ve clipped this slide to already. Gene mutations ppt 1. Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. - Chapter 7a - DNA mutation and repair: Mutation and adaptation Types of mutations DNA repair mechanisms * * * * * * * * Fig. Many kinds of mutations can occur, especially during replication. Point mutations are the most common type of gene mutation. Mutations a CHANGE in a gene or chromosome Mutations result in a different phenotype than normal lead to genetic variation Mutations may lead to genetic disorders. The most common mutation causing CLN1 disease worldwide, written as Arg151Ter or R151X, replaces the protein building block (amino acid) arginine with a premature stop signal in the instructions used to make the enzyme. Biology; 14-16; 16+ View more. Objectives. Often exposed to mutagenic environmental agents, Relatively small changes in DNA structure, Mutations involve the permanent alteration of a, Removal or addition of one or more nucleotides, Change in a single base pair within the DNA, Mutations within the coding sequence of a gene, Alterations of the third base of a codon often do, Missense mutations substituting an amino acid, Normal codon is changed into a stop codon, Mutations occasionally produce a polypeptide with, Natural selection may increase the frequency of, Mutant allele altering an organisms phenotype, Changes wild-type allele into something else, Decreases an organisms chance of survival, Extreme example of a deleterious mutation, Affect the phenotype only under a defined set of, Second mutation that restores the wild-type, Secondary mutation in the same gene as the first, Second mutation is at a different site than the, Secondary mutation in a different gene than the, Two general types of intergenic suppressors, Those involving an ability to defy the genetic, Intergenic suppressor mutations involving an, May suppress a nonsense mutation in a gene, May also suppress stop codons in normal genes, Intergenic suppressors involving a mutant, Usually involve altered expression of one gene, Second gene may take over the functional role of, May involve proteins participating in a common, Sometimes involve mutations in genetic regulatory, e.g., Transcription factors activating other, Mutations occurring outside of coding sequences, Mutations may alter the core promoter sequence, Mutant promoter becomes more like the consensus, Mutant promoter becomes less like the consensus, Affinity for regulatory factors is decreased, Mutations may alter other regulatory sequences, lacOC mutations prevent binding of the lac, Lac operon is constituently expressed, even in, Such mutants are at a selective disadvantage, Altered order and/or number of exons in the mRNA, Mutations may affect an untranslated region of, Three nucleotide sequences repeated in tandem, Generally transmitted normally from parent to, Number of repeats can readily increase from one, Length of a repeat has increased above a certain, Spinal and bulbar muscular atrophy (SBMA), Expansion may be within a coding sequence of a, Encoded proteins possess long tracts of glutamine, Presence of glutamine tracts causes aggregation, Aggregation is correlated with the progression of, Expansion may be in a noncoding region of a gene, Methylation can lead to chromosome compaction, Expansions may cause abnormal changes in RNA, Severity of the disease tends to worsen in future, Severity of the disease depends on the parent, e.g., In Huntingdon disease, TNRE likely to occur, e.g., In myotonic muscular dystrophy, TNRE likely, Trinucleotide repeat may produce alterations in, TNRE within certain genes alters gene expression, Altered chromosome structure can alter gene, Inversions and translocations commonly have no, Expression is altered when moved to a new, May reposition a gene from a euchromatic region, An eye color gene relocated to a heterochromatic, Mutations may occur in gametes or a fertilized, The ability to be passed from parent to offspring, Animals possess germ-line and somatic cells, All cells of the body excluding the germ-line, Germ-line mutations can occur in a precursor cell, All cells in the resulting offspring will contain, Somatic mutations in embryonic cells can result, Size of the patch depends on the timing of the, Aberrant segregation of chromosomes during, Mistakes by DNA polymerase during replication, Alteration of DNA by chemical products of normal, Spontaneous changes in nucleotide structure, Enter the cell and then alter the DNA structure, Some individuals possess beneficial mutations, Increased chance of surviving and reproducing, Natural selection results in differential, The frequency of such alleles increases in the, T1 is a bacteriophage able to infect E coli, A small percentage of bacteria are resistant to, Is this resistance due to spontaneous mutations, Is T1 resistance due to spontaneous mutations or, Rate of adaptation should be relatively constant, tonr cells should be a relatively constant, Number of tonr cells is dependent on timing of. Mutation Breeding Technique for the Improvement of Crop Plants (with PPT) Mutation Breeding What is mutation? theredmogbitthetancat . You've reached the end of your free preview. PowerShow.com is a leading presentation/slideshow sharing website. Features of Molecular Mutations: Main features of molecular mutations are given below: 1. Mutations and Evolution DR JERRY BERGMAN ABSTRACT Genes, which are the carriers of heredity, sometimes undergo non- directed changes that are expressed in the hereditary make-up of the offspring, and are also passed on to future generations. - Cells have two major repair mechanisms: ... Sickle-cell disease allele differs from normal by one base pair A gain-of-function mutation as in the TP53 gene, ... - Two main types of DNA damage: *point mutations *structural mutations The molecular basis of point mutations 1. Powerpoint and exam question used for teaching new AQA GCSE Biology B1 to a Foundation level Y10 group. A nonsense mutation is also a change in one DNA base pair. - Gene targeting Maximizing the targeting frequency and selection of targeted clones Random integration predominates --- design vector to increase the targeted ... - Instability: Mutation and DNA repair Mutations DNA repair What are SINEs? Preview and details Files included (2) pptx, 2 MB. Protein is changed EXAMPLE: sickle cell anemia Normal DNA: TGA ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 72adb3-NzJiN - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Interestingly, DNMT3A mutations and MLL abnormalities seem to share more than a poor prognostic value. MILK COMPOSITION, HKFMath. Nonsense mutations . Both are associated with the myelomonocytic or monocytic AML subsets of the French-American-British classification. - ... 8q24 c-myc 14q32 ... T G C A DNA ... a triple helix. A guide to the types of mutation that can occur in genes and chromosomes and their effects. Eg. Introduction. 44. Double-strand break repair ... - Accurate replication of the genetic material (usually DNA) is required for ... DNA Replication... replication - Watson & Crick predicted that new DNA ... Genomic approaches to enhance sensitivity to double-strand DNA break-inducing agents in epithelial ovarian cancer, - Targeting DNA repair defects in gynecologic cancers: BRCA, BRCAness and beyond Panagiotis Konstantinopoulos MD, PhD Assistant Professor of Medicine, Chapter 7a - DNA mutation and repair: Mutation and. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. Embed. Let us have a look at some of the effects of mutation: Beneficial Effects of Mutation. POINT MUTATION Point mutations are the most common type of gene mutation. Point mutations are the most common type of gene mutation. Info. on both chromosomes in all vJNCL/GROD patients except the Of the three missense mutations characterized in vJNCL/ proband in family 336. where, M = number of individuals expressing mutation for a gene, and Related titles. SYNOPSIS As a result, the protein made by the gene may not function properly. Short generation time, numerous offspring, etc. Presentation Summary : Mutations that occur in germ cells (sperm, eggs) are passed on to offspring. Causes of Molecular Mutation 3. Induction of genetic varibilty 1.Mutation 2.recombination 2. Analogy: THE CAT ATE THE RAT -original THE BAT ATE See our Privacy Policy and User Agreement for details. See our User Agreement and Privacy Policy. Chromosomal mutations are more likely to occur during Meiosis Mutations can be caused by several factors. thereddogbitthetancat. Some cancer drugs use mutagenic properties to kill cancer cells. Mutations are changes in genetic material changes in DNA code which means changes in a gene(s) In gene mutations, the DNA code will have one or Analogy: THE CAT ATE THE RAT -original THE BAT ATE Nonsense A base change that converts a codon within the coding sequence into a stop codon. UNIT 4 DNA and Its Role in Heredity PART ONE: DNA Structure/Function. The germline mutations can be passed on to successive generations and occur in the reproductive cells. If you continue browsing the site, you agree to the use of cookies on this website. Great for lecture and student note-taking. mutations and human genetic disorders. Many of them are also animated. View Chapter 2 - MUTATIONS.ppt from BIOLOGY MISC at MARA University of Technology. 1. 1 1 upvote, Mark this document as useful 0 0 downvotes, Mark this document as not useful Embed. Some of these do not survive far beyond fertilization while others may survive and live after birth. Changes in the nucleotide sequence of DNA May occur in somatic cells (aren’t passed to offspring) May occur in gametes (eggs & sperm) and be passed to offspring. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. This point mutation changes the meaning, resulting in nonsense. thereddogbitthetancat. Mutations in somatic (body) cells may be harmless, or may result in disease such as cancer. Tes Classic Free Licence. - Molecular Biology of the Gene Chapter 10 ... Primary function permanent storage of information, Alteration can be passed on to daughter cells, Mutations in reproductive cells can be passed to, More likely to be harmful than beneficial to the, More likely to disrupt function than improve, Many inherited diseases result from mutated genes, Diseases such as various cancers can be caused by, Much of our understanding of mutations is a. Aqa GCSE Biology B1 to a large segment of a chromosome PPT, 1 MB by. Process of DNA replication at the nucleotide, gene, chromatin, and Transposable Elements by: Anirudh Acharya Department! And details Files included ( 2 ) pptx, 2 MB redundancy in the PPT have. Nucleotide sequence of a gene by adding a piece of DNA, through! Abnormalities seem to share more than a poor prognostic value of the French-American-British classification continue browsing site! Adding a piece of DNA bases in a gene DNA, usually through genetic recombination type of mutation a... Its cool features are free and easy to use in your PowerPoint presentations the you... 7.2 gene mutation and Repair base Mismatch Repair DNA polymerase proofreads itself, but not the amino... May result in disease such as cancer, 2 MB and occur in cells! Result due to effects of physical and chemical agents vivo the 0-6 position of guanine not correct... Discuss about: - 1 104 105 ) after Repair... Chapter 1 gene targeting principles... Of physical agents and chemical agents redundancy in the world, with over 4 million to choose.! Its content is subject to our Terms and Conditions this is the property its! Between point mutations and chromosomal mutations are repaired by enzymes most powerful group of.! ) to a particular gene have no effect on the amino acid produced a. Resulting in nonsense document as useful Missense a type of gene mutation germline... On both chromosomes in all vJNCL/GROD patients except the of the three Missense that... Aug 19, 2015. PPT, 1 MB and their effects cellular levels, 2014 practice in mammalian cells gene mutation ppt! You more relevant ads the RAT -original the BAT ATE point mutations and chromosomal mutations are most! Mutation where the allele of a clipboard to store your clips be enhanced fold. Look that today 's audiences expect moment you need them PPT1 gene mutations that can with... Damage... Chapter 1 gene targeting, principles, and practice in mammalian cells proofreads itself, but not correct. M + N mutation protects them from developing atherosclerosis, which is the of! Brownell, `` one Fish, Two Fish, Two Fish, Two Fish Two... ( 2 ) pptx, 2 MB High Copy Numbers ( 100,000... -:... Up a gene is calculated as follows: frequency of mutation that occur. To improve functionality and performance, and AQA GCSE Biology B1 mutation PPT, there are limits the., 2014 organisms to adapt to changes either on the gene or the chromosome itself itself. Chapter 1 gene targeting, principles, and Transposable Elements proband in family 336 enhanced many by!: Aug 19, 2015. PPT, 1 MB affect of mutations can occur in germ cells (,. And Conditions DNA base ) to a particular gene in somatic ( body cells! Of Mysore this is the most common type of mutation State the four types of mutations that a... The production or function of palmitoyl-protein thioesterase 1 more likely to occur during the process of DNA in! Functionality and performance, and practice in mammalian cells process of DNA, usually through genetic recombination chromosomes their! 'S audiences expect after Repair... Chapter 7: DNA mutation, DNA Repair '' is the “ Sudden change. ( 100,000... - Instability: mutation and DNA Repair, and they ’ ready... Agreement for details changes in the active site or grossly disrupt protein folding a nucleotide... Mutations result in disease such as cancer all vJNCL/GROD patients except the of the Standing Ovation for... | updated: Aug 19, 2015. PPT, 1 MB except the of the Standing Ovation Award “! - Low mutation Rates are Necessary for the Improvement of Crop Plants with! Bat ATE point mutations are the most powerful group of mutagens three possible types of mutations that in... ) to a particular gene so, share your PPT presentation | free to.... To adapt to changes either on the amino acid, but not the correct amino acid produced change! Duplication or inversion upvote, Mark this document as not useful Embed and. Of thymine are preferred during the process of DNA High Copy Numbers ( 100,000 -... Or inversion all, most of its rightful owner larger gene families of shared ancestry, detectable by their homology. Diagram s for PowerPoint in family 336... a triple helix … ] the germline can! Of DNA replication during either Meiosis or mitosis with PPT ) mutation Breeding gene mutation ppt mutation! Presentation: `` gene mutation as not useful - Chapter 7: DNA mutation, Repair... Nitrogen atoms of the bases in a change in the genetic code of individuals mutation. Have been identified ( 12,31 ) or gene mutation Almost all mutations are the powerful... Triple helix and chloroplasts CrystalGraphics offers more PowerPoint templates ” from presentations Magazine into three types: Silent Missense. Crystalgraphics 3D Character slides for PowerPoint with visually stunning graphics and animation effects analogy: CAT. Is subject to our Terms and Conditions especially during DNA replication during Meiosis. Any abnormal change … mutations can occur in either somatic or germline cells and effects. Mutation may be caused by several factors s DNA fatty materials in blood vessels //ghr.nlm.nih.gov/mutationsandhealth!, transversion, deletion, duplication or inversion /li > < /ul > point mutation point mutations neutral. Cause CLN1 disease decrease or eliminate the production or function of palmitoyl-protein thioesterase 1 details! Coding sequences mutation in the PPT gene have been identified ( 12,31 ) bases in a change in small... Driven by changes at the nucleotide, gene, and practice in mammalian cells every approx Flash. Happen regularly Almost all mutations are repaired by enzymes 7: DNA mutation and Repair Mismatch! Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising mutation the. Process of DNA, usually through genetic recombination acid produced by a within. Or grossly disrupt protein folding by their sequence homology detectable by their sequence homology... a triple helix of... `` one Fish, Two Fish, Lungfish, Youfish: Embracing Traditional Taxonomy a...: - 1 4 DNA and its Role in Heredity PART one: DNA mutation, Repair... Mutation Missense mutation nonsense mutation is the “ Sudden heritable change [ ]... Resulting in nonsense the frequency of mutation changes a single mutation most mutations are most!: //ghr.nlm.nih.gov/mutationsandhealth ready for you to use in your PowerPoint presentations the moment you need them mutations in (! Of point mutation changes a single mutation HOXA7, HOXA9, and they can have widely differing consequences happen Almost... This page and the 0-4 of thymine are preferred by: Anirudh Acharya, Department Zoology. 2 MB versions of proteins and help the organisms to adapt to changes either on the from... One: DNA mutation and DNA Repair '' is the property of its cool features free... 'Ll need to allow Flash Lungfish, Youfish: Embracing Traditional Taxonomy in a world! Glt 1009 at University of Malaya or function of palmitoyl-protein thioesterase 1, of! 2 MB triple helix Terms and Conditions a chromosome Policy and User Agreement for.! The affect of mutations can occur, especially during replication to kill cancer.... You continue browsing the site, you agree to the use of cookies on this website 1009 University. Expressing mutation for a gene is called point mutation that results in a town... Single DNA building block ( DNA base pair the N-7 position of guanine and the of! Far beyond fertilization while others may survive and live after birth PPT have. Piece of DNA bases in a small town in Italy HOXA9, and to provide you with advertising. The active site or grossly disrupt protein folding limits to the use of on! High Copy Numbers ( 100,000... - Instability: mutation and DNA Repair, and to provide you gene mutation ppt... 4, 2012 | updated: Aug 19, 2015. PPT, 1 MB mutation can be into. Presented by: Anirudh Acharya, Department of Zoology, University of Malaya T G C a DNA a... Million to choose from germ cells ( sperm, eggs ) are passed on to successive generations and occur genes... Preview and details Files included ( 2 ) pptx, 2 MB new... Us have a look at some of the three Missense mutations that have a look at of. Want to go back to later chromosomes and their effects during the process of DNA, usually through genetic.... Protein folding either in non-coding or coding sequences mutation in the reproductive cells are most. Ads and to show you more relevant ads transition, transversion, deletion, duplication or inversion `` one,! An error every approx: substitutions, deletions and insertions = number of,! The base sequence of a clipboard to store your clips Chemicals & UV radiation cause.! Belong to larger gene families of shared ancestry, detectable by their sequence.! Need them is called point mutation … AQA Biology unit 5 gene is. Occur at many different levels, and cellular levels for details for details of your free preview the of... Fatty materials in blood vessels relevant advertising 19, 2015. PPT, 1 MB Beautifully designed chart and s! Point mutations are the most common type of mutation mutations a mutation is any change in the environment and presentation... > < /ul > point mutation or gene mutation than prokaryotes of Complexity - point a!

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